Contrasting Actions of Cis- and Trans-Clomiphene on the Release of FSH and FSH-RF in the Female Rat
- 1 January 1970
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 2 (06) , 344-348
- https://doi.org/10.1055/s-0028-1095051
Abstract
An investigation was carried out on the effect of cis-clomiphene and trans-clomiphene upon the release of FSH in the oophorectomized, estrogen-progesterone blocked rat. Contrasting actions of the cis-isomers and trans-isomers could be shown. Cis-clomiphene was found to lower the hypothalamic content of FSH-RF and of pituitary FSH. As a consequence, there was a rise of plasma FSH in inverse proportions. The injection of 150 µg/rat proved to be most effective. When higher doses were given the level of plasma FSH fell, and the pituitary FSH and hypothalamic FSH-RF content rose.Keywords
This publication has 0 references indexed in Scilit: