Augmentation of Mitogen-Induced Interleukin 2 Production by Oral Administration of Polysaccharide SPR-901
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 14 (3) , 403-420
- https://doi.org/10.3109/08923979209005401
Abstract
The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α-1,3 branched α-1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α-1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.Keywords
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