Delineation of Two Antigenic Markers, “Non a” and “Non g” Related to the Genetic Antigens of Human γ Globulin

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Abstract
Summary: Two new antigenic markers have been described which supplement the known Gm genetic antigens. The first, “non a,” represents a genetic marker for the γG1 subgroup but occurs in all γG2 and γG3 proteins. The second, “non g,” is a genetic marker for the γG3 subgroup but is found in addition on all γG2 proteins. Rabbit and primate antisera to these determinants were readily produced and measurements were carried out by hemagglutination-inhibition. The two antigens appear to reflect the basic amino acid sequences that were modified as a result of the genetic events leading to Gm (a) and Gm (g), respectively. Several examples were cited where the new markers proved informative. It seems probable that failure to appreciate the strong “non a” antigen has lead to confusion regarding certain genetic antigens reported previously.

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