Hereditary Iron-Loading Anemia with Secondary Hemochromatosis

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Abstract
Five cases manifesting a distinctive form of refractory hypochromic anemia complicated consistently by the later development of hemochromatosis have been studied in an attempt to define further what appears to be a unique clinical entity, one that has been infrequently recognized previously. Uncomplicated primary, or idiopathic, hemochromatosis only rarely is associated with significant anemia (1). It appears instead to result from an increased intestinal absorptive capacity for dietary iron, this malfunction possibly being inherited and occurring in the absence of anemia or other hematologic abnormalities. Exogenous hemochromatosis has been described in a variety of patients with longstanding refractory anemias, most