Detection by Immune Electron Microscopy of 27-nm Viral Particles Associated with Community-Acquired Diarrhea in Children

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Abstract
The proportion of diarrheal illnesses of unknown origin that were associated with small round virus (SRV, 23-38 nm) particles among children P < .04). Of6 patients with available acute and convalescent sera, 4 demonstrated a significant immune response when tested by IBM. All patients experienced a mild, self-limited (1–3 days) illness. These findings suggest that SRV may be endemic in the Baltimore community and may result in clinically significant diarrheal illnesses.