SYNOVIORTHESIS WITH P-32-LABELED COLLOIDAL CHROMIC PHOSPHATE IN RHEUMATOID-ARTHRITIS - CLINICAL, HISTOPATHOLOGIC AND ARTHROGRAPHIC CHANGES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 9  (2) , 229-238
Abstract
Synoviorthesis was performed in 217 joints from 111 patients suffering from different stages of rheumatoid arthritis (RA). 32P-colloidal chromic phosphate was employed, with an average dose from 6 mCi for large joints (knees) to 0.3 mCi for small peripheral joints such as the metacarpophalangeal joints. Satisfactory clinical results were observed in 84% of the cases and no significant side effects resulted after a follow-up period from 1-10 yr. Striking effects after treatment were observed through histopathological studies (light and EM) and the use of contrast arthrography. Radioactive synovectomy with 32P-chromate is a very useful method for the local treatment of RA.