PLASMA AND SYNOVIAL-FLUID CONCENTRATIONS OF PIROXICAM DURING PROLONGED TREATMENT WITH PIROXICAM PIVALIC ESTER

  • 1 May 1987
    • journal article
    • research article
    • Vol. 37-1  (5) , 560-563
Abstract
Piroxicam pivalic ester (CHF 10/21) is a prodrug of piroxicam and is characterized by a reduced gastric irritant activity. Plasma and synovial fluid samples were simultaneously taken from 7 patients with mono- or poly-articular arthritis causing knee effusion, during 4 weeks of treatment with CHF 10/21 at the dose of 30 mg/day. The time courses of plasma levels of both the prodrug and the active principle were studied and a correlation of the latter with synovial fluid levels was made. After 14 days of treatment the steady-state was reached in the systemic (plasma) and peripheral (synovial fluid) compartments with therapeutically active drug levels. Clinical results were good and a complete disappearance of local pain occurred in 2 cases. Good gastric tolerance was also achieved.

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