Immunopharmacology of CpG Oligodeoxynucleotides and Ribavirin
Open Access
- 1 June 2004
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (6) , 2314-2317
- https://doi.org/10.1128/aac.48.6.2314-2317.2004
Abstract
To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.Keywords
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