Human Aminopeptidases: A Review of the Literature
- 1 January 1988
- journal article
- review article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 26 (12) , 795-807
- https://doi.org/10.1515/cclm.1988.26.12.795
Abstract
The aminopeptidases constitute a group of enzymes with closely related activities. In clinical chemistry the analysis of the aminopeptidases and of their multiple forms in serum has for a long time been hindered by considerable confusion concerning their identification, and by a lack of characterization. This is in part due to the often large, and sometimes overlapping substrate specificities of the aminopeptidases. This paper reviews the biochemical properties of the different aminopeptidases, the specificities of the assays used for their analysis in serum, some aspects of their multiple forms--which are especially known to occur for alanine aminopeptidase (EC 3.4.11.2)--and the importance of the determination of aminopeptidases and their multiple forms in clinical chemistry.Keywords
This publication has 32 references indexed in Scilit:
- Characterization of three aminopeptidases purified from maternal serumBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Degradation of low-molecular-weight opioid peptides by vascular plasma membrane aminopeptidase MBiochimica et Biophysica Acta (BBA) - General Subjects, 1986
- Characterization of Membrane‐Bound Aminopeptidases from Rat Brain: Identification of the Enkephalin‐Degrading AminopeptidaseJournal of Neurochemistry, 1985
- A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domain.The Journal of cell biology, 1983
- Sequential hydrolysis of proline-containing peptides with immobilized aminopeptidasesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
- Brush border membrane hydrolysis of S-benzyl-cysteine-p-nitroanilide, an activity of aminopeptidase MBiochemical and Biophysical Research Communications, 1980
- On the hydrophobic part of aminopeptidase and maltases which bind the enzyme to the intestinal brush border membraneBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- Studies on plasma membranes. VII. A leucyl-β-naphthylamidase-containing repeating unit on the surface of isolated liver and hepatoma plasma membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1968
- Leucine aminopeptidase in human serum: comparison of hydrolysis of l-leucylglycine and l-Leucyl-β-NaphthylamideClinica Chimica Acta; International Journal of Clinical Chemistry, 1964
- Leucine aminopeptidase in human serum: an ultramicromethod for the determination of the rates of hydrolysis of L-LeucylglycineClinica Chimica Acta; International Journal of Clinical Chemistry, 1964