Mebendazole and alveolar hydatid disease

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Abstract
Five patients with far-advanced, non-resectable Echinococcus multilocularis infection received high-dose mebendazole therapy for 6 yr. The growth of progressively enlarging primary hepatic lesions (3 cases) and thoracic metastases (2 cases) was arrested with regression of lesions in each case. On 2 occasions, tissues of the larval cestode from a patient who had received long-term mebendazole therapy failed to develop viable vesicles after animal [rodent] inoculation. Survival time has been almost certainly prolonged. The favorable results seen in this clinical trial are attributable to mebendazole therapy.

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