Studies on Metabolism of Trazodone. III. Species Differences
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 6 (5) , 295-306
- https://doi.org/10.3109/00498257609151641
Abstract
1. After oral administration of [14C] trazodone HC1 (4 mg/kg) to rabbits, the blood level of radioactivity shows a peak at 3 h; unchanged trazodone concentration in brain is higher than that in plasma at 3 h after dosage. 2. The metabolic fate of trazodone in rabbits is different from that in rats and a new, basic metabolite is present in rabbit liver, brain, plasma and urine. 3. The concentration pattern in blood of humans given a single dosage (50 mg) of trazodone HC1 is similar to that in rabbits rather than that in rats. 4. The rate of metabolism of trazodone by liver microsomes from mice is approximately 1.5 times higher than that with rat or rabbit liver microsomes.This publication has 7 references indexed in Scilit:
- Studies on Metabolism of Trazodone, II. Metabolic Fate after Intravenous Administration and Effects on Liver Microsomal Drug-Metabolizing Enzymes in RatsXenobiotica, 1974
- Studies on Metabolism of Trazodone, I. Metabolic Fate of [14C]Trazodone Hydrochloride in RatsXenobiotica, 1974
- Investigations on the specificity of the so-called analgesic activity of non-narcotic drugsEuropean Journal of Pharmacology, 1970
- Pharmacological properties of AF 1161, a new psychotropic drugInternational Journal of Neuropharmacology, 1968
- Biliary excretion in foreign compounds. Species difference in biliary excretionBiochemical Journal, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951