INTERACTION OF METAL-IONS WITH NUCLEIC-ACIDS - INTERACTION OF COPPER(II) WITH GUANOSINE AND ITS DERIVATIVES
- 1 January 1978
- journal article
- research article
- Vol. 25 (2) , 101-111
Abstract
The interaction of Cu(II) with guanosine, 2''-deoxyguanosine, 1-methylguanosine, 7-methylguanosine and GMP was studied by spectroscopic and magneto-chemical methods. The main site of Cu(II) binding in guanosine is N-7; participation of N-1 is not excluded. The involvement of the carbonyl O in Cu binding or Cu chelation to N-7 and O-6 is rather unlikely. A crystalline complex of Cu(II) with GMP [Cu(C10H12O8N5P).cntdot.(H2O)3] was obtained, in which Cu(II) was bound to N-7 and the phosphate group.This publication has 4 references indexed in Scilit:
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