Inhibitory Effect of Charcoal-Treated Porcine Follicular Fluid upon Serum FSH Levels and Follicular Development in the Rhesus Monkey

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Abstract
Porcine follicular fluid (pFF1) has been shown to contain a nonsteroidal FSH suppressing substance active in castrated (1) and intact (2) adult female rats. However, the follicular fluid did not inhibit serum LH. The role of physiological levels of FSH in controlling follicular development and ovulation in the rhesus monkey is not known, since there are no methods available other than immunization against FSH which can selectively and reversibly remove FSH without removing LH at the same time. Based on the findings in the rat, it seemed feasible that pFF1 might also depress serum FSH levels in the rhesus monkey. In order to examine the role of the FSH secreted early in the menstrual cycle in the rhesus monkey, a series of injections of pFFl have been employed to depress serum FSH early in the menstrual cycle. Serum FSH, LH, estrogen and progesterone levels were measured during the treated and control cycle to monitor the effects of the pFFl. In addition, the dynamics of using pFFl to suppress peripheral serum FSH levels were examined in both postmenopausal and long term castrated female monkeys, where sustained hyper-secretions of both FSH and LH may dramatize the selective suppression of circulating FSH by pFF1.

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