Genetic variation at the adipsin locus and response to long-term overfeeding

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Abstract
Objectives: The role of adipsin and adipsin Hinc II polymorphisms on the metabolic and body composition changes in response to overfeeding was studied. Subjects: A total of 12 pairs of male monozygotic twins ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. Results: The preoverfeeding plasma adipsin concentration correlated positively with the change in CT-measured abdominal total and subcutaneous (PPPn=10) than in 6.1 kb carriers (n=14) of the adipsin Hinc II polymorphism. The 6.1 kb noncarriers had a greater increase in plasma leptin levels (PPPPP<0.05) levels increased more in the 6.1 kb noncarriers than in the 6.1 kb carriers. Conclusions: Adipsin plasma level could be a predictor of the changes in abdominal subcutaneous fat during times of increased energy intake. However, a greater increase in the abdominal subcutaneous fat was related to a lower increase in the plasma adipsin level. The adipsin Hinc II 6.1 kb allele noncarriers gained more abdominal subcutaneous fat and had a greater increase in plasma levels of leptin- and triglyceride-rich lipoproteins when exposed to a long-term positive energy balance. These findings provide new information on the role of adipsin on individual differences in response to chronically elevated food intake.