Studies in relation to biosynthesis. XLI. Canescin
- 1 January 1969
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 22 (11) , 2429-2436
- https://doi.org/10.1071/ch9692429
Abstract
The biosynthesis of canescin (I) has been investigated. The isocoumarin portion is derived from a polyketide chain. One carbon atom of the γ- lactone ring and the carbon atom of the methoxyl group originate from methionine whilst the other three carbon atoms of the γ-lactone have a symmetrical C4-acid of the citric acid cycle as their precursor. This metabolite is most unusual in that an oxygenated methionine-derived carbon atom provides the growing point of a new carbon chain. A possible mechanism for the attachment of the lactone is suggested.Keywords
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