Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

Abstract
Pregnancy-associated plasma protein-A (PAPP-A) and inhibition of phytohemagglutinin (PHA)-induced lymphocyte transformation were measured in 51 seminal plasma samples obtained from oligozoospermic (n = 22), normospermic (n = 22), and vasectomized men (n = 7). In nonvasectomized men, PAPP-A significantly correlated with the percentage inhibition of lymphocyte transformation. The possibility of PAPP-A being an immunosuppressive principle of human seminal plasma is discussed.

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