Complement activation and anaphylactoid response to protamine in a child after cardiopulmonary bypass.
- 1 May 1985
- Vol. 53 (5) , 574-576
- https://doi.org/10.1136/hrt.53.5.574
Abstract
A 2 1/2 year old boy had a sudden, severe, and unexpected anaphylactoid reaction after an otherwise uncomplicated repair of a partial atrioventricular septal defect. The reaction, comprising haemorrhagic pulmonary oedema and peripheral circulatory collapse, followed neutralisation of heparin by protamine. Measurements of serum complement (C3 and C4) concentrations suggested that a pronounced consumption of complement occurred during the adverse response.Keywords
This publication has 13 references indexed in Scilit:
- Cardiovascular effects of protamine sulfate in manThe Journal of Thoracic and Cardiovascular Surgery, 1982
- Complement activation and neutropenia occurring during cardiopulmonary bypassThe Journal of Thoracic and Cardiovascular Surgery, 1981
- Complement Activation during Cardiopulmonary BypassNew England Journal of Medicine, 1981
- Production of acute pulmonary injury by leukocytes and activated complement.1980
- Noncardiogenic Pulmonary Edema and Peripheral Vascular Collapse Following Cardiopulmonary Bypass: Rare Protamine Reaction?The Annals of Thoracic Surgery, 1980
- Anaphylaxis to protamine sulfate mediated by a complement-dependent IgG antibodyJournal of Allergy and Clinical Immunology, 1978
- Chemical Aspects of the Serum AnaphylatoxinsPublished by Springer Nature ,1978
- Anaphylactic Shock in the Monkey: its Hemodynamics and Mediators1Acta Anaesthesiologica Scandinavica, 1977
- INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEMThe Journal of Experimental Medicine, 1974
- Cardiorespiratory effects of protamine after cardiopulmonary bypass in manThorax, 1974