Fluorinated Analogs of DDT as Toxicants and DDT Synergists

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Abstract
The insecticidal activities and ability to synergize DDT of 16 fluorine-containing structural analogs of DDT were determined. Of the 2,2-difluoro-1,1-di-p-halophenyl derivatives of ethane, ethanol and ethyl acetate, the p-bromo- and p-chloro- compounds were about equally toxic to susceptible house flies (Musca domestica L.) and the p-fluoro-compounds were less toxic. The ethane, ethanol, and ethyl acetate derivatives decreased in toxicity in the order given. The t1uorodiphcnylethenes were not significantly toxic to house flies. Maximum synergistic activity with DDT occurred in those derivatives containing p-chloro- or bromo-groups, fluoro- being inferior in all cases. Synergistic activity varied with the nature of the group attached to the alpha carbon atom in the following order: OH>H>OCOCH3. The fluorodiphenylethenes were the least active p-halophenyl synergists. The difluorodiphenyl compounds containing no halogen substituent in the benzene ring were devoid of synergistic activity.

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