Effect of Stilboestrol and Testosterone on the Incorporation of75Selenomethionine by Prostatic Carcinoma Cells

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Abstract
Controversy still exists as to whether oestrogns exert a direct effect on the prostatic cell. Incorporation of 75Selenomethionine (SeM) was used as a measure of protein synthesis by prostatic carcinoma cells in vitro to investigate the action of hormones on prostatic carcinoma cells in tissue culture. Stiboestrol (DES) and stilboestrol diphosphate (Honvan) inhibited protein synthesis in a patients with benign hyperplasia (BPH). This work confirms that oestrogens have a direct inhibitory effect on prostatic cells at high concentrations which can be attained in patients given intravenous stiboestrol diphosphate.