Cross-Protection between Tacaribe Complex Viruses. Presence of Neutralizing Antibodies against Junin Virus (Argentine Hemorrhagic Fever) in Guinea Pigs Infected with Tacaribe Virus

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Abstract
Cross-protection between Junin virus and five other Tacaribe complex viruses and the serological response of guinea pigs inoculated with Tacaribe virus are reported here. Previous infection with Tamiami or Pichinde viruses significantly delayed guinea pig deaths. A 58% survival rate was found among animals immunized with three doses of Amapari virus, while guinea pigs inoculated with one dose of Machupo or Tacaribe virus were fully protected against Junin virus. Neutralization tests performed in serum samples of guinea pigs immunized with five doses of Tacaribe virus showed that they developed homologous and heterologous neutralizing antibodies.