In Vitro Studies of the Interactions of PuIV with Blood Proteins

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Abstract
The binding of PuIV to bovine albumin, canine alpha, beta, and gamma-globulin, and blood cells and plasma proteins of beagle hounds was studied in vitro. Basically, all those proteins tested are capable of interacting with PuIV in vitro. Blood cells exhibited a low affinity for PuIV. There was no penetration of PuIV through cell membranes, although isolated hemoglobin was able to bind PuIV. In plasma, PuIV was associated primarily with the low-molecular-weight proteins consisting of albumin and a globulin, and to a lesser extent with constituents having a molecular weight greater than 200, 000.