OVARIAN THERAPY

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Abstract
Since Birch's1 announcement of the treatment of hemophilia with ovarian extract, several papers by herself2 and others3 reporting beneficial results from the administration of this hormone have appeared in the literature. However, the conclusions arrived at have not been very convincing. The improvement was chiefly clinical and in most instances not substantiated by definite laboratory data. It is difficult to determine whether the hormone had a specific effect in bringing about the clinical improvement. Moreover, Birch2a attempted to correlate hemophilia with the female sex hormone. Assuming that the normal male is not pure male but part female, Birch demonstrated that the female sex hormone or estrogenic substance was present in the urine of normal males and absent from the urine of five hemophiliac patients. Based on those results, it is assumed that the symptoms of hemophilia are held in abeyance by the female sex hormone. Because

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