2-(3-Methylthiopropyl)-1H-benz[d,e]isoquinoline-1,3(2H)-dione derivatives as novel photo-induced DNA cleavers
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 311-312
- https://doi.org/10.1039/c39950000311
Abstract
The efficient DNA cleavage of ϕx 174 DNA is observed in the longer wavelength ( > 350 nm) irradiation of 2-(3-methylthiopropyl)-1H-benz[d,e]isoquinoline-1,3(2H)-diones 1a–e, but not in the cases of 2-isobutyl-1H-benz[d,e]isoquinoline-1,3(2H)-diones 1f, g which is explained by considering the participation of persulfoxirane intermediate 4 in the DNA photocleavage.Keywords
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