SPECIES AND STRAIN COMPARISON OF ACUTE NEUROTOXIC EFFECTS OF TRIMETHYLTIN IN MICE AND RATS

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 5  (3) , 337-350
Abstract
Pathological changes in the CNS in 2 strains of mice (BALB/c and C57BL/6) and 2 strains of rats (Long Evans [LE] and Sprague Dawley [SD]) as a result of trimethyltin (TMT) intoxication were compared. Both strains of mice were administered trimethyltin chloride at 3.0 mg TMT-Cl/kg body wt while both strains of rats were exposed to 7.5 mg TMT-Cl/kg body wt. Animals were sacrificed at the time of development of observable neurological signs (tremor, aggression): 2 days for both strains of mice, 3 days for LE rats and 5 days for SD rats. There were species and strain differences in TMT toxicity. Despite being exposed to a lower dose of TMT and for a shorter duration of time, mice showed more prominent neurological signs and hippocampal lesions. Among the 2 strains of rats studied, LE rats were more sensitive to TMT toxicity. The regional sensitivity of the CNS between mice and rats was also different, with mice showing most lesions in the hippocampal fascia dentata and rats showing more prominent neuronal damages in the olfactory cortices and hippocampal Ammon''s horn.