Propranolol in the control of blood pressure: A dose-response study

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Abstract
In a double-blind crossover study the hypotensive response to propranolol in 24 patients with essential hypertension was no greater at doses of 80, 160 or 240 mg twice daily than at 40 mg twice daily. A relationship was observed between dose and response as defined by the ability to achieve a standing diastolic blood pressure of 95 mm Hg. Patients (4) with low plasma renin activity had no fall in blood pressure even at highest dose levels. Plasma propranolol levels in the groups were related to dose, and up to a concentration of 300 ng/ml, with degree of .beta.-adrenoceptor blockade; there was no correlation with hypotensive response.