Alu sequences
Open Access
- 3 November 1997
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 417 (1) , 1-5
- https://doi.org/10.1016/s0014-5793(97)01259-3
Abstract
Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies. In recent years a number of different functional roles for Alu sequences have been described. The multiple influences of Alu sequences on RNA polymerase II‐mediated gene expression and the presence of Alu sequences in RNA polymerase III‐generated transcripts are discussed.Keywords
This publication has 76 references indexed in Scilit:
- Two partial deletion mutations involving the same Alu sequence within intron 8 of the LDL receptor gene in Korean patients with familial hypercholesterolemiaHuman Genetics, 1997
- Study of Alu sequences at the hypoxanthine phosphoribosyltransferase (hprt) encoding region of manGene, 1997
- The Rate of CpG Mutation inAluRepetitive Elements within the p53 Tumor Suppressor Gene in the Primate GermlineJournal of Molecular Biology, 1996
- Comparative sequence analysis of the human and pufferfish Huntington's disease genesNature Genetics, 1995
- Splice-mediated insertion of an Alu sequence in the COL4A3 mRNA causing autosomal recessive Alport syndromeHuman Molecular Genetics, 1995
- Identifying coding exons by similarity search: Alu-derived and other potentially misleading protein sequencesGenomics, 1992
- ‘Brain-specific’ transcription and evolution of the identifier sequenceNature, 1986
- Selfish genes, the phenotype paradigm and genome evolutionNature, 1980
- DNA methylation and the frequency of CpG in animal DNANucleic Acids Research, 1980
- A ubiquitous family of repeated DNA sequences in the human genomeJournal of Molecular Biology, 1979