THE BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF 6‐AMINODOPAMINE: SIMILARITY WITH 6‐HYDROXYDOPAMINE

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Abstract
6‐aminodopamine was injected intraperitoneally into male Swiss–Webster mice. At 72 h post injection 6‐aminodopamine had caused a reduction in the endogenous content of heart norepinephrine, a decrease in the capacity of heart slices to accumulate [3H]‐norepinephrine in vitro, and a virtual disappearance of the adrenergic plexus of the mouse iris as viewed by fluorescence histochemistry. Similar data were obtained with the same dose of 6‐hydroxydopamine. These data suggest that 6‐aminodopamine causes a destruction of sympathetic nerve terminals. Model experiments showed that 6‐aminodopamine, like 6‐hydroxydopamine, generated H2o2both in vitro and in vivo. 6‐Aminodopamine, like 6‐hydroxydopamine, also blocked the accumulation of [3H]dopamine into slices of rat brain in vitro.