Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.
- 15 October 1993
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (20) , 9576-9580
- https://doi.org/10.1073/pnas.90.20.9576
Abstract
In the mammalian neostriatum, dopamine modulates neuronal responses mediated by activation of excitatory amino acid receptors. The direction of this modulation varies with the specific subtype of excitatory amino acid receptor activated. Responses evoked by iontophoretic application of glutamate (Glu) and the non-N-methyl-D-aspartate (NMDA) agonists quisqualate and alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid were significantly attenuated when dopamine was applied. In contrast, responses evoked by NMDA were markedly potentiated. The enhancement of NMDA-evoked excitations was mimicked by bath application of SKF 38393, a D1 receptor agonist. The D1 receptor antagonist SCH 23390 blocked the dopamine enhancement of NMDA-induced excitations. Quinpirole, a D2 receptor agonist, attenuated responses evoked by both NMDA and non-NMDA receptor agonists. These results indicate that the complex modulatory actions of dopamine in the neostriatum are a function of the excitatory amino acid receptor as well as the specific dopamine receptor subtype activated. These findings are of clinical relevance since the actions of dopamine and excitatory amino acids have been implicated in neurological and affective disorders.Keywords
This publication has 51 references indexed in Scilit:
- New wave of non-NMDA excitatory amino acid receptorsTrends in Pharmacological Sciences, 1991
- Molecular biology of the dopamine receptorsEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Influence of age on N‐methyl‐D‐aspartate antagonist binding sites in the rat brain studied by in vitro autoradiographySynapse, 1991
- Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neuronsNeuroscience Letters, 1991
- A Family of AMPA-Selective Glutamate ReceptorsScience, 1990
- Dopaminergic modulation of cholinergic responses in rat medial prefrontal cortex: an electrophysiological studyBrain Research, 1990
- The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neuronesTrends in Neurosciences, 1990
- Interactions between dopamine and amino acid-induced excitation and inhibition in the striatumBrain Research, 1986
- Excitation by dopamine D-2 receptor agonists, bromocriptine and LY 171555, in caudate nucleus neurons activated by nigral stimulationLife Sciences, 1986
- Axo-Axonic Synapses in the Rat StriatumEuropean Neurology, 1983