Foveal sensitivity changes in retinitis pigmentosa

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Abstract
Loss in foveal sensitivity in retinitis pigmentosa (RP) has been attributed to a decrease in quantal catching ability. Using a psychophysical technique (the probe–flash paradigm), we previously found that the results obtained for six RP patients under light adapted conditions were not consistent with a quantal catch hypothesis. To test further this hypothesis twelve RP patients were examined in dark adapted conditions. Probe thresholds were normal for five patients and increased for seven patients. The decreased quantal catching hypothesis was rejected for six of the seven patients.

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