An interpretation of the serum alkaline phosphatase isoenzyme patterns in patients with obstructive liver disease.
- 1 November 1976
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 29 (11) , 976-980
- https://doi.org/10.1136/jcp.29.11.976
Abstract
Earlier studies have identified two main isoenzymes of alkaline phosphatase in the sera of patients with obstructive liver disease. This paper reports on a study of these isoenzymes in specific types of liver disease where the pathology in relation to bile duct obstruction is known. The results have been used to support the theory that in biliary obstruction the increase in serum alkaline phosphatase is in part due to regurgitation of the biliary isoenzymes.Keywords
This publication has 25 references indexed in Scilit:
- Some properties of alkaline-phosphatases in parenchymal and biliary tract cells separated from rat liverClinica Chimica Acta; International Journal of Clinical Chemistry, 1975
- The nature of the serum alkaline phosphatases in liver diseasesJournal of Clinical Pathology, 1974
- Quantitative Differentiation of Human Serum Alkaline Phosphatase Isoenzymes with Polyacrylamide Disc Gel Electrophoresiscclm, 1973
- The nature of the alkaline phosphatases of bileJournal of Clinical Pathology, 1972
- A comparative study of alkaline phosphatase enzymes using starch-gel electrophoresis and sephadex gelfiltration with special reference to high molecular weight enzymesClinica Chimica Acta; International Journal of Clinical Chemistry, 1970
- Induction of rat liver alkaline phosphatase: the mechanism of the serum elevation in bile duct obstructionJournal of Clinical Investigation, 1970
- Enzyme assays in liver disease.Journal of Clinical Pathology, 1970
- Phosphatasen, V. Intrazelluläre Verteilung der Isoenzyme der alkalischen Phosphatase der Rattenleber und ihr Verhalten nach Unterbindung des Ductus choledochusHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1967
- Liver DiseaseBMJ, 1966
- Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrineJournal of Clinical Pathology, 1954