Thrombolytic Treatment of Venous Thromboembolism

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Abstract
Thrombolytic drugs, such as streptokinase, urokinase or heparin, provide a new therapeutic modality for the management of intravascular thrombosis. They provide an opportunity for the rapid restoration of blood flow in a vessel occluded by a fibrin clot. At the same time they may induce hemorrhage by lysis of hemostatic fibrin plugs. Careful patient selection coupled with expertise in the mechanisms of action and laboratory control of thrombolytic agents is essential if an optimal benefit to risk ratio is to be achieved.