Sulfhydryl and Disulfide Content of Normal and Arsenic-Resistant Trypanosomes.

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Abstract
The acetone-dried proteins of normal and arsenic-resistant strains of Trypanosoma equiperdum and of T. hippicum were analyzed for sulfhydryl and disulfide content. The cysteine equivalent of sulfhydryl in all 4 strains ranged from 0.27 to 0.4 mg. per g. of protein and differences between strains were not significant. The cysteine equivalent of disulfide in a normal strain of T. equiperdum (6 mg./g.) was more than that of an arsenic-resistant strain (1.77 mg./g.) whereas in T. hippicum the order was reversed (1.49 mg./g. normal, 2.1 mg./g. resistant). It was concluded that these differences were not responsible for arsenic-resistance.