Studies on the Antimalarial Effects of Cycloguanil Pamoate (CI-501) in Man

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Abstract
Summary Studies on the antimalarial effects of cycloguanil pamoate (CI-501) were conducted with healthy, adult, male volunteers. Investigations were carried out in a non-malarious area and under conditions precluding reinfection. Evidence obtained confirmed findings reported previously by other workers indicating that a single intramuscular dose of CI-501 can confer protection for months against patency of sporozoite-induced infections with the Chesson strain of Plasmodium vivax. CI-501 did not exert a similar long-lasting protective effect against sporozoite-induced infections with strains of chloroquine-resistant (and chlorguanide-resistant) P. falciparum from Southeast Asia.

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