Clinical and Biochemical Study of Subretinal Fluid Globulins Examined by Disc Electrophoresis

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Abstract
Subretinal fluid and serum from 34 patients with retinal detachment were excmined using disc electrophoresis on polyacrylamide gel. A quantitative evaluation of 4 groups of globulin fractions, namely post-albumin (POST) fraction, transferrin (T) fraction, polyglobulin (POLY) fraction and macroglobulin (MACRO) fraction, has been made, and it was found that the fractions POST and T, in comparison to serum, are considerably increased while the fractions POLY and MACRO of subretinal fluid are decreased. There was a significant reduction in POST and an increase in POLY fractions present in cases of retinal detachment more than 3 months old and those affecting large areas of the retina. The level of T fraction was lower in cases when retina failed to become attached after operation.

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