A SCREENING TEST FOR THE MALIGNANT HYPERPYREXIA PHENOTYPE USING SUXAMETHONIUM-INDUCED CONTRACTURE OF MUSCLE TREATED WITH CAFFEINE, AND ITS INHIBITION BY DANTROLENE
Open Access
- 1 August 1979
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 51 (8) , 753-756
- https://doi.org/10.1093/bja/51.8.753
Abstract
Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P < 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene.This publication has 2 references indexed in Scilit:
- ANAESTHESIA FOR PATIENTS SUSCEPTIBLE TO MALIGNANT HYPERPYREXIA: A study of pancuronium and methylprednisoloneBritish Journal of Anaesthesia, 1977
- Action on calcium movements in frog sartorius muscles by drugs producing rigorJournal of Cellular and Comparative Physiology, 1963