Reactivation of folate-binding protein from cow's milk, purified by affinity chromatography in the presence of lecithin and other surfactants

Abstract
Purification by affinity chromatography of the folate-binding protein from cow''s milk leads to a drastic lowering of the affinity of the protein for folate. The purified protein was completely reactivated in the presence of a number of surfactants (phospholipids and synthetic detergents) particularly of cationic or non-ionic type. There is a striking analogy between the present results and the well-known lipid/detergent reactivation of certain purified membrane-derived enzymes.

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