Teratogenicity of 27.12‐MHz radiation in rats is related to duration of hyperthermic exposure

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Abstract
Five groups of pregnant Sprague‐Dawley rats were either sham exposed or were irradiated in a 27.12‐MHz radiofrequency (RF) field at 55 A/m and 300 V/m on gestation day 9. The absorbed power (approximately 11 W/kg) caused a relatively rapid increase in the rat's colonic temperature. Rats in group I were sham irradiated for 2.5 h at 0 A/m, 0 V/m. In group II RF irradiation was terminated after the rat's colonic temperature reached 41.0 °C. In group III the 41.0‐ °C temperature was maintained an additional 15 min by varying the field strength. At both temperatures the teratogenic and embryotoxic effects of the RF‐induced hyperthermia increased as the exposure duration increased, but the increase was especially noticeable at 42.0 °C. The results indicate that the teratogenic and embryotoxic effects of RF‐induced hyperthermia are related to both the temperature of the dam during exposure and the length of time the dam's temperature remains elevated.