EFFECT OF PHENYLINDANEDIONE AND DICUMAROL IN EXPERIMENTAL FROSTBITE

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Abstract
Rabbits and rats were exposed to frostbite and treated with the anticoagulants phenylindanedione and dicumarol. Phenylindanedione and dicumarol therapy did not prevent the formation of gangrene after frostbite, but did prolong the onset of gangrene in both rabbits and rats. Death from hemorrhage occurred after anticoagulant therapy in rabbits exposed to frostbite. Frostbite alone did not alter the prothrombin time of rabbits, but in rats it resulted in a significant increase in the prothrombin time. The rabbits showed a much greater increase in prothrombin time with the anticoagulants after frostbite.