ENTERAL HYPEROXALURIA - EFFECT OF CHOLESTYRAMINE, CALCIUM, NEOMYCIN, AND BILE-ACIDS ON INTESTINAL OXALATE ABSORPTION IN MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (3) , 193-200
Abstract
The effect of oral administration of cholestyramine, neomycin, Ca and bile acids on intestinal 14C-oxalate absorption and urinary oxalate excretion was assessed in patients with normal or increased (enteric hyperoxaluria) urinary oxalate excretion. Cholestyramine, neomycin and acute administration of chenodeoxycholic acid (2.75 g/24 h) did not significantly affect 14C-oxalate absorption or urinary oxalate excretion. Oral administration of Ca markedly reduced 14C-oxalate absorption (88.2%) and urinary oxalate excretion (46%). Ca-induced reduction of intestinal oxalate absorption was more pronounced in patients with hyperabsorption of oxalate than in subjects with normal oxalate absorption or excretion. Patients on treatment with high of chenodeoxycholic acid (1.5-2.0 g/day) for dissolution of cholesterol gallstones had increased oxalate absorption and excretion, while patients on long-term treatment with lower doses of chenodeoxycholic acid (0.75-1.0 g/day) exhibited normal absorption of urinary excretion of oxalate. Ca and bile acids apparently play an important role in pathogenesis of enteric hyperoxaluria. The beneficial therapeutic effect of cholestyramine in hyperoxaluria due to ileal resection is probably caused by its bile acid binding property rather than by direct binding of oxalate within the intestinal lumen.

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