The gene for hepatocyte nuclear factor (HNF)‐4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver
- 24 July 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 478 (1-2) , 141-146
- https://doi.org/10.1016/s0014-5793(00)01840-8
Abstract
The gene for a transcription factor hepatocyte nuclear factor-4α (HNF-4α) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4α gene in the liver. Stimulation of primary-cultured rat hepatocytes with dexamethasone or glucagon led to induction of HNF-4α mRNA, being antagonized by insulin. In the liver of streptozotocin-induced diabetic rat, mRNA and protein levels for HNF-4α were elevated, and were normalized by insulin treatment. Therefore, HNF-4α in the liver is likely to be involved in the regulation of glucose metabolism in response to these hormones.Keywords
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