EFFECT OF THIAZIDES ON METACORTICOID HYPERTENSION AND ON THYROID ACTIVITY OF RATS

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Abstract
Chronic oral administration of either chlorothiazide (3.8 g/kg food) or hydrochlorothiazide (0.6 g/kg food) provides significant protection against metacorticoid hypertension induced by desoxycorticosterone trimethylacetate (post-DTMA hypertension) in rats as assessed by smaller heart weight and lower systolic blood pressure than in controls. Ratio of thyroid weight to body weight is increased by drug treatment. Both thiazides also appear to affect activity of the thyroid gland in that rate of loss of I131 is increased whereas both radioactivity of the excised thyroid gland and thyroid to serum ratio of radioactivity are reduced. Rate of oxygen consumption by chlorothiazide-treated rats is also reduced. In addition, histological appearance of the thyroid glands of both treated groups show extreme (chlorothiazide) to moderate (hydrochlorothiazide) stimulation. It is apparent that these drugs affect both size and activity of the thyroid gland at the dose levels used. It cannot be stated with certainty whether the effect of these drugs on the thyroid gland is associated with their antihypertensive property.