ANALYSIS OF THE INHIBITION OF THE ACTH RELEASE BY HYPOTHALAMIC IMPLANTS OF ATROPINE

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Abstract
The effect of anterior hypothalamic atropine implants on the secretion of corticotrophin in the rat, as indicated by the corticosteroid production by adrenal glands incubated in vitro and/or by the plasma corticosterone concentration, was studied. It was found that atropine implants markedly inhibit the adrenocortical responses evoked by all the stress stimuli tested, except for that to a CRF preparation. The onset of the blockade was very fast; the duration of the inhibition lasted for about 2 h. Smaller amounts of atropine (2×15 μg) were also effective when implanted bilaterally into the anterior hypothalamic region. It is concluded that cholinergic synapses in the hypothalamus may be involved in the activation of the pituitary-adrenal system after stressful stimuli.

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