Hyperchylomicronemia and Hypercholesterolemia: Their Correlation with Clinical Atherosclerosis

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Abstract
The application of dark field microscopy to the study of lipids in fasting human serum is discussed. The results obtained in 77 cases of myocardial infarction and 216 non-infarction cases are presented and statistically analyzed for degree of correlation with the incidence of myocardial infarction. Statistically higher chylomicron levels were found in the myocardial infarction cases when compared with non-infarction individuals of the same age group and sex, except in the 65 years-and-older group. Peak levels of chylomicrons and total cholesterol were observed in the 45–54-year-olds in the infarction group, while in the nonfarction group this peak was found in the oldest age groups. Women in the age group 65 years and over, with no demonstrable clinical evidence of atherosclerosis, were found to have significantly elevated chylomicron levels when compared with younger men and women. The levels of total cholesterol were found to show significant correlation with the incidence of myocardial infarction in this series of cases.