THE INFLUENCE OF IRON-DEXTRAN COMPLEX ON THE STRAIN L FIBROBLAST

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Abstract
The strain L cell has been grown in medium containing massive doses (500 [mu]g per milliliter medium) of iron-dextran complex, Imferon. Morphology, growth, and respiration of these cells have been studied for a 3 month period. The cytoplasm of strain L cells grown in iron-dextran medium contained pigment which gave a positive Prussian-blue reaction. The multinucleated cells consistently contained more pigment than the mononuclear cells. Growth was markedly reduced whereas respiration was only slightly curtailed. The mechanism of entry of the iron-dextran complex into the cell was discussed.

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