The stimulation by endotoxin of the nonspecific resistance of mice to bacterial infections.

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  • 1 April 1974
    • journal article
    • Vol. 55  (2) , 194-202
Abstract
The nonspecific resistance of mice to challenge was enhanced following the administration of an E. coli O55 B5 endotoxin. Although the route of administration of the endotoxin and the challenge organism were varied, the nonspecific resistance of the animal was enhanced in all the experiments. The efficiency of this resistance was highest when the inducing substance and the challenge dose of bacteria were administered intraperitoneally. Poly I: C and double stranded RNA were also studied but were much less effective than endotoxin in stimulating a resistance to infection.