PAEONIFLORIN REVERSES GUANETHIDINE‐INDUCED HYPOTENSION VIA ACTIVATION OF CENTRAL ADENOSINE A1 RECEPTORS IN WISTAR RATS
- 7 October 1999
- journal article
- research article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 26 (10) , 815-816
- https://doi.org/10.1046/j.1440-1681.1999.03132.x
Abstract
SUMMARY 1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine‐induced hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8‐cyclopentyl‐1,3‐dipropylxanthine inhibited this effect of paeoniflorin in a dose‐dependent manner. 3. The action of paeoniflorin was not modified by 8‐(p‐ sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine‐induced hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.Keywords
This publication has 6 references indexed in Scilit:
- Stimulatory effect of paeoniflorin on adenosine A-1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUT 4) in isolated rat white adipocytesLife Sciences, 1998
- Antihyperglycemic Effects of Paeoniflorin and 8-Debenzoylpaeoniflorin, Glucosides from the Root ofPaeonia lactifloraPlanta Medica, 1997
- Punicalagin-induced release of norepinephrine reverses orthostatic hypotension in ratsPhytotherapy Research, 1994
- Peony and its major constituent, paeoniflorin, improved radial maze performance impaired by scopolamine in ratsPharmacology Biochemistry and Behavior, 1993
- Tail-cuff blood pressure measurement without external preheating in awake rats.Hypertension, 1982
- Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed ratBritish Journal of Pharmacology, 1973