SPS-B, a physiological sleep regulator, from the brainstems of sleep-deprived rats, identified as oxidized glutathione.
- 1 January 1990
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (7) , 2057-2059
- https://doi.org/10.1248/cpb.38.2057
Abstract
We previously reported regarding the "sleep-promoting substance (SPS)," which was isolated from the brainstem extract of sleep-deprived rats, the existence of multiple active components including uridine and SPS-B. Intracerebroventricular infusion of crude SPS-B exhibited significant enhancing on both slow wave sleep and paradoxical sleep in unrestrained rats. Further investigations of SPS-B gtutamylcysteinylglycine disulfide. Authentic GSSG similarly administered in rats also significantly enhanced sleep which was indistinguishable from normal physiological sleep. We propose GSSG as a candidate endogenous sleep substance.This publication has 5 references indexed in Scilit:
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