Effect of Age in Rodent Models of Focal and Forebrain Ischemia
- 1 September 1996
- journal article
- Published by Wolters Kluwer Health in Stroke
- Vol. 27 (9) , 1663-1668
- https://doi.org/10.1161/01.str.27.9.1663
Abstract
Background and Purpose The majority of animal experiments examining the nature and treatment of stroke have used relatively young animals ranging in age from 2 to 6 months. However, significant morphological, neurochemical, and behavioral changes occur with aging in rodents, particularly during the first 24 months of age. This study examines the effect of age in two models of transient ischemia, a forebrain and a focal model, in male Wistar rats.Keywords
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