Activity of CI -960 alone and in combination with amoxycillin against Listeria monocytogenes, and comparison with other quinolones
- 1 September 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 36 (3) , 527-530
- https://doi.org/10.1093/jac/36.3.527
Abstract
In-vitro activity of CI-960 against seven strains of Listeria monocytogenes was compared to that of other fluoroquinolones. MICs/MBCs were: ciprofloxacin and sparfloxacin: 0.5–2/1–4 mg/L; PD 131628: 0.125–0.5/0.25–2 mg/L; CI-960: 0.06–0.25/ 0.25–0.5 mg/L. At 4 h, CI-960 (4 x MIC) reduced the inoculum (log10 cfu) by 2.88 ± 0–61 compared with 1 –78 ± 0.48 for ciprofloxacin, 1.5 ± 0.46 for sparfloxacin, and 1.35 ± 0.47 for PD 131628 (P < 005). At 24 h, the bactericidal effects were similar (±4 logiocfu). The amoxycillin/CI-960 (8 x MIC) combination was bactericidal, without emergence of resistant mutants.Keywords
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