Cortisol Regulation of Gamma-Glutamyl Transpeptidase in Liver, Choroid Plexus, Blood Plasma and Cerebrospinal Fluid of Developing Chick Embryo

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Abstract
A relationship between membrane-bound .gamma.-glutamyl transpeptidase (GGT) in liver and choroid plexus and the soluble GGT in blood plasma and cerebrospinal fluid is indicated by a decrease of the former activity in the organs and a concomitant increase of the latter in the body fluids of the embryonic chick between day 11 and hatching. starting on day 15, the administration of cortisol caused a marked increase in the activity of soluble GGT in blood plasma and cerebrospinal fluid which might be related to an increase of the membrane-bound activity of this enzyme by the glucocorticoid in liver, brain and choroid plexus during the same developmental period. Before day 15 cortisol reduced GGT activity in the liver and choroid plexus suggesting a biphasic effect of the steroid on the activity of membrane-bound GGT.